Trans Fats And Fructose Can Develop Into Fatty Liver Disease

Diets high in trans fats and fructose can lead to fatty liver disease and liver fibrosis. This is according to a study, titled High-fructose, medium chain trans fat diet induces liver fibrosis conducted by at the Metabolic Disease Institute at the University of Cincinnati. The study was also published in the journal “Hepatology”.

Even though the study was conducted with mice, the progression of the fatty liver disease in mice closely resembles the progression of the disease in humans. This allowed the researchers to study and understand the development of obesity related fatty liver disease.

Two groups of mice were studied. One group were fed a normal diet of rodent chow with a healthy calorie content. The other group were fed a high calorie, 16-week diet of fructose enriched water and trans fat solids.

The researchers discovered that the mice who were fed the normal amount of chow remained lean, and did not develop fatty liver disease. The mice who were fed the high calorie diet of either just trans fats or a combination of trans fats and
fructose became obese and developed fatty liver disease.

In addition, it was discovered that the mice who were fed both trans fats and fructose also developed the more advanced stage of fatty liver which included scarring of the liver. This is also known as liver fibrosis.

In the United States, the average diet consumes about ten percent of its calories as fructose. Excessive consumption of
both fructose and table sugar have been linked to health problems such as obesity, cardiovascular disease and liver disease.

That is why it is stressed that to maintain good liver health, you should eat healthy. Try to avoid processed foods with
added fructose or sugar. Focus on eating a Mediterranean type of diet which includes a lot of fruits and vegetables, nuts, seeds, fish and extra-virgin olive oil.

In summary, researchers have found that a high calorie diet with excessive amounts of trans fats and fructose can lead to fatty liver disease, and the more advanced form of the disease with liver scaring.

References

High-fructose, medium chain trans fat diet induces liver fibrosis

For additional information, see Fatty Liver Diet.